SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab

Qingyun Yang; Tingkai Xiang; Yangfan Wu; Enyi Ye; Beilei He; Zhangyu Bu

doi:10.2147/CCID.S384346

SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab

Clin Cosmet Investig Dermatol. 2022 Nov 28:15:2547-2554. doi: 10.2147/CCID.S384346. eCollection 2022.

Authors

Qingyun Yang^#¹, Tingkai Xiang^#¹, Yangfan Wu^#¹, Enyi Ye^#¹, Beilei He^#¹, Zhangyu Bu^#²

Affiliations

¹ Department of The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006 People's Republic of China.
² Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.

^# Contributed equally.

Abstract

Introduction: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is an acronym for synovitis, pustulosis, acne, hyperostosis, and osteitis, and clinically manifests as dermatological and musculoskeletal damage. Two major manifestations that co-occur in a single patient are rare.

Methods/results: This literature describes a 44-year-old male affected by SAPHO syndrome, whose first manifestation was palmoplantar pustulosis (PPP). Symptomatic treatments such as anti-inflammatory and analgesics did not work well for him. Adalimumab provided noteworthy improvement in the neck and thoracic back pain improvement after two weeks. The palmoplantar pustules were alleviated after four weeks.

Conclusion: The literature on SAPHO syndrome therapy is increasing. Thus, adalimumab is a novel therapeutic agent. This report demonstrates the efficiency of adalimumab in SAPHO syndrome.

Keywords: acne; adalimumab; bone hypertrophy; osteitis; psoriasis; psoriasis arthritis; synovitis.

Publication types

Case Reports

Grants and funding

This work was supported by the Hangzhou Science and Technology Committee Grant numbers: 20191203B94, Medical Science and Technology Project of Zhejiang Province Grant numbers: 2020RC095, Zhejiang Province Public Welfare Technology Application Research Project Grant numbers: LGF19H110001, Medical Science and Technology Project of Zhejiang Province Grant numbers: 2018KY578.