The role of mesenchymal stem cell transplantation for ischemic stroke and recent research developments

Li Zhou; Jiani Wang; Jiagui Huang; Xiaosong Song; Youlin Wu; Xia Chen; Yongjun Tan; Qin Yang

doi:10.3389/fneur.2022.1000777

The role of mesenchymal stem cell transplantation for ischemic stroke and recent research developments

Front Neurol. 2022 Nov 16:13:1000777. doi: 10.3389/fneur.2022.1000777. eCollection 2022.

Authors

Li Zhou¹, Jiani Wang¹, Jiagui Huang¹, Xiaosong Song¹, Youlin Wu¹, Xia Chen¹, Yongjun Tan¹, Qin Yang¹

Affiliation

¹ Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Abstract

Ischemic stroke is a common cerebrovascular disease that seriously affects human health. However, most patients do not practice self-care and cannot rely on the current clinical treatment for guaranteed functional recovery. Stem cell transplantation is an emerging treatment studied in various central nervous system diseases. More importantly, animal studies show that transplantation of mesenchymal stem cells (MSCs) can alleviate neurological deficits and bring hope to patients suffering from ischemic stroke. This paper reviews the biological characteristics of MSCs and discusses the mechanism and progression of MSC transplantation to provide new therapeutic directions for ischemic stroke.

Keywords: experimental treatment; ischemic stroke (IS); mesenchymal stem cells (MeSH ID: D059630); stem cell transplantation (HSCT); stem-cell based therapy.

Publication types

Review