Chromatographic Separation of Aromatic Amine Isomers: A Solved Issue by a New Amphiphilic Pillar[6]arene Stationary Phase

ACS Appl Mater Interfaces. 2022 Dec 21;14(50):56132-56142. doi: 10.1021/acsami.2c17889. Epub 2022 Dec 6.


In this work, the fabrication, synthesis, and characterization of a new stationary phase based on an amphiphilic pillar[6]arene (P6A-C10-2NH2) for gas chromatographic analyses are reported. The gas chromatography (GC) column prepared with P6A-C10-2NH2 stationary phase exhibited a medium polarity, an efficiency of 3219 plates/m, and unmatched resolving capabilities toward chloroaniline, bromoaniline, iodoaniline, and toluidine isomers. Furthermore, the P6A-C10-2NH2 column showed excellent repeatability with maximum relative standard deviations equal to 0.02, 0.07, and 2.56% for run-to-run, day-to-day, and column-to-column, respectively, demonstrating a great potential as a new stationary phase in separation science.

Keywords: aromatic amine isomers; gas chromatography; pillar[n]arenes; separation sciences; stationary phase.