Production of medical isotope 68Ge based on a novel chromatography separation technique and assembling of 68Ge/68Ga generator

Jieru Wang; Ruiqin Gao; Shiwei Cao; Zhi Qin; Mu Lin; Qinggang Huang; Zeen Yao

doi:10.1016/j.apradiso.2022.110599

Production of medical isotope ⁶⁸Ge based on a novel chromatography separation technique and assembling of ⁶⁸Ge/⁶⁸Ga generator

Appl Radiat Isot. 2023 Feb:192:110599. doi: 10.1016/j.apradiso.2022.110599. Epub 2022 Nov 30.

Authors

Jieru Wang¹, Ruiqin Gao², Shiwei Cao², Zhi Qin³, Mu Lin², Qinggang Huang², Zeen Yao⁴

Affiliations

¹ Laboratory of Nuclear Chemistry, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730000, China; School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100010, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516003, China.
² Laboratory of Nuclear Chemistry, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516003, China.
³ Laboratory of Nuclear Chemistry, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100010, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516003, China. Electronic address: qinzhi@impcas.ac.cn.
⁴ School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730000, China.

PMID: 36476417
DOI: 10.1016/j.apradiso.2022.110599

Abstract

A double-column chromatography separation technique was involved for isolation of ⁶⁸Ge from a bombarded Ga-Ni alloy target. About 185 MBq ⁶⁸Ge obtained was used for assembling SnO₂-based ⁶⁸Ge/⁶⁸Ga generator. Approximately 70% of ⁶⁸Ga in high radioactivity concentration was eluted from generator with excellent radionuclidic, radiochemical and chemical purity. ⁶⁸Ga was quite adequate for radiolabeling with DOTATATE or PSMA-617 with a high labelling efficiency of >92%. The double-column chromatography technique possessed a potential application prospect of ⁶⁸Ge/⁶⁸Ga production, aiding the development of ⁶⁸Ga in nuclear medicine.

Keywords: Double-column chromatography separation technique; Ga–Ni target; Separation of (68)Ge; SnO(2)-based (68)Ge/(68)Ga generator.

MeSH terms

Gallium Radioisotopes* / chemistry
Radiochemistry / methods
Radioisotopes*
Radiopharmaceuticals / chemistry

Substances

Gallium Radioisotopes
Radioisotopes
Radiopharmaceuticals