Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage

Rui Liu; Qianming Chen

doi:10.1016/j.cmet.2022.11.006

Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage

Cell Metab. 2022 Dec 6;34(12):1897-1898. doi: 10.1016/j.cmet.2022.11.006.

Authors

Rui Liu¹, Qianming Chen²

Affiliations

¹ State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: liurui_scu@hotmail.com.
² State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: qmchen@scu.edu.cn.

PMID: 36476930
DOI: 10.1016/j.cmet.2022.11.006

Abstract

The rapid increase of dNTP pools in mammalian cells upon DNA damage has been previously documented. Alterations in protein modifications or interactions can rapidly modulate the activity and protein stability of mammalian RNR, and activation of PRPS1/2-dependent generation of PRPP enhances the production of the indispensable ribose sugar for nucleotide biosynthesis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA Damage*
Polyphosphates

Substances

triphosphoric acid
Polyphosphates