A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease

Inga Steinbrenner; Zhi Yu; Jin Jin; Ulla T Schultheiss; Fruzsina Kotsis; Morgan E Grams; Josef Coresh; Matthias Wuttke; GCKD Investigators; Florian Kronenberg; Kai-Uwe Eckardt; Nilanjan Chatterjee; Peggy Sekula; Anna Köttgen

doi:10.1016/j.kint.2022.11.013

A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease

Kidney Int. 2023 Feb;103(2):421-424. doi: 10.1016/j.kint.2022.11.013. Epub 2022 Dec 5.

Authors

Affiliations

¹ Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
² Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
³ Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
⁴ Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany; Department of Medicine IV-Nephrology and Primary Care, University of Freiburg, Freiburg, Germany.
⁵ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA; Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
⁶ Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
⁷ Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany; Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁸ Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
⁹ Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. Electronic address: anna.koettgen@uniklinik-freiburg.de.

PMID: 36481179
PMCID: PMC9868068 (available on 2024-02-01)
DOI: 10.1016/j.kint.2022.11.013

Abstract

Keywords: chronic kidney disease; kidney function; polygenic score.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Kidney
Multifactorial Inheritance*
Renal Insufficiency, Chronic* / diagnosis
Renal Insufficiency, Chronic* / genetics
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding