Glomerular diseases in pregnancy: pragmatic recommendations for clinical management

Kidney Int. 2023 Feb;103(2):264-281. doi: 10.1016/j.kint.2022.10.029. Epub 2022 Dec 5.


Our understanding of the various aspects of pregnancy in women with kidney diseases has significantly improved in the last decades. Nevertheless, little is known about specific kidney diseases. Glomerular diseases are not only a frequent cause of chronic kidney disease in young women, but combine many challenges in pregnancy: immunologic diseases, hypertension, proteinuria, and kidney tissue damage. An international working group undertook the review of available current literature and elicited expert opinions on glomerular diseases in pregnancy with the aim to provide pragmatic information for nephrologists according to the present state-of-the-art knowledge. This work also highlights areas of clinical uncertainty and emphasizes the need for further collaborative studies to improve maternal and fetal health.

Keywords: fetal complications; glomerular diseases; immunosuppressive drugs; kidney biopsy; pregnancy.

Publication types

  • Review

MeSH terms

  • Clinical Decision-Making
  • Female
  • Humans
  • Kidney
  • Pregnancy
  • Pregnancy Complications* / diagnosis
  • Pregnancy Complications* / etiology
  • Pregnancy Complications* / therapy
  • Pregnancy Outcome
  • Renal Insufficiency, Chronic* / complications
  • Renal Insufficiency, Chronic* / diagnosis
  • Renal Insufficiency, Chronic* / therapy
  • Uncertainty