Current advances on the therapeutic potential of pinocembrin: An updated review

Biomed Pharmacother. 2023 Jan:157:114032. doi: 10.1016/j.biopha.2022.114032. Epub 2022 Dec 5.

Abstract

Pinocembrin (5,7-dihydroxyflavone) is a major flavonoid found in many plants, fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies revealed numerous pharmacological activities of pinocembrin including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective and anticancer activities. Here, we comprehensively review and critically analyze the studies carried out on pinocembrin. We also discuss its potential mechanisms of action, bioavailability, toxicity, and clinical investigations. The wide therapeutic window of pinocembrin makes it a promising drug candidate for many clinical applications. We recommend some future perspectives to improve its pharmacokinetic and pharmacodynamic properties for better delivery that may also lead to new therapeutic advances.

Keywords: Biosynthesis; Clinical trials; Gut microbiota; Pharmacokinetics; Pharmacological activities; Pinocembrin.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents* / pharmacology
  • Anti-Infective Agents* / therapeutic use
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / pharmacology
  • Flavanones* / pharmacokinetics
  • Flavanones* / therapeutic use
  • Flavonoids

Substances

  • Flavanones
  • Antioxidants
  • Flavonoids
  • Anti-Inflammatory Agents
  • Anti-Infective Agents