Prostate volume, baseline urinary function, and their association with treatment choice and post-treatment urinary function in men treated for localized prostate cancer

doi:10.1038/s41391-022-00627-1

Multicenter Study

. 2023 Dec;26(4):787-794.

doi: 10.1038/s41391-022-00627-1. Epub 2022 Dec 8.

Prostate volume, baseline urinary function, and their association with treatment choice and post-treatment urinary function in men treated for localized prostate cancer

Jacob E Tallman¹, Christopher J D Wallis², Zhiguo Zhao³, Li-Ching Huang³, David F Penson², Tatsuki Koyama³, Michael Goodman⁴, Ann S Hamilton⁵, Xiao-Cheng Wu⁶, Lisa E Paddock⁷, Antoinette Stroup⁷, Matthew R Cooperberg⁸, Mia Hashibe⁹, Brock B O'Neil¹⁰, Sherrie H Kaplan¹¹, Sheldon Greenfield¹¹, Karen E Hoffman¹², Daniel A Barocas²

Affiliations

¹ Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA. jacob.tallman@vumc.org.
² Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
³ Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴ Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
⁵ Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
⁶ Department of Epidemiology, Louisiana State University New Orleans School of Public Health, New Orleans, LA, USA.
⁷ Department of Epidemiology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
⁸ Department of Urology, University of California, San Francisco, CA, USA.
⁹ Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
¹⁰ Department of Urology, University of Utah Health, Salt Lake City, UT, USA.
¹¹ Department of Medicine, University of California Irvine, Irvine, CA, USA.
¹² Department of Radiation Oncology, University of Texas M. D. Anderson Center, Houston, TX, USA.

PMID: 36482081
PMCID: PMC11229171 (available on 2024-12-01)
DOI: 10.1038/s41391-022-00627-1

Multicenter Study

Prostate volume, baseline urinary function, and their association with treatment choice and post-treatment urinary function in men treated for localized prostate cancer

Jacob E Tallman et al. Prostate Cancer Prostatic Dis. 2023 Dec.

. 2023 Dec;26(4):787-794.

doi: 10.1038/s41391-022-00627-1. Epub 2022 Dec 8.

Authors

Affiliations

¹ Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA. jacob.tallman@vumc.org.
² Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
³ Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴ Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
⁵ Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
⁶ Department of Epidemiology, Louisiana State University New Orleans School of Public Health, New Orleans, LA, USA.
⁷ Department of Epidemiology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
⁸ Department of Urology, University of California, San Francisco, CA, USA.
⁹ Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
¹⁰ Department of Urology, University of Utah Health, Salt Lake City, UT, USA.
¹¹ Department of Medicine, University of California Irvine, Irvine, CA, USA.
¹² Department of Radiation Oncology, University of Texas M. D. Anderson Center, Houston, TX, USA.

PMID: 36482081
PMCID: PMC11229171 (available on 2024-12-01)
DOI: 10.1038/s41391-022-00627-1

Erratum in

Correction to: Prostate volume, baseline urinary function, and their association with treatment choice and post-treatment urinary function in men treated for localized prostate cancer.
Tallman JE, Wallis CJD, Zhao Z, Huang LC, Penson DF, Koyama T, Goodman M, Hamilton AS, Wu XC, Paddock LE, Stroup A, Cooperberg MR, Hashibe M, O'Neil BB, Kaplan SH, Greenfield S, Hoffman KE, Barocas DA. Tallman JE, et al. Prostate Cancer Prostatic Dis. 2023 Dec;26(4):809. doi: 10.1038/s41391-023-00658-2. Prostate Cancer Prostatic Dis. 2023. PMID: 36890265 No abstract available.

Abstract

Background: Benign prostatic hyperplasia, lower urinary tract symptoms, and prostate cancer often co-occur. Their effect on urinary function is an important consideration regarding prostate cancer treatment choices. While prostate volume (PV) and urinary symptoms are commonly used in treatment choice decision making, their association with post-treatment urinary function is unknown. We evaluated the associations between PV and baseline urinary function with treatment choice and post-treatment urinary function among men with localized prostate cancer.

Methods: We identified 1647 patients from CEASAR, a multicenter population-based, prospective cohort study of men with localized prostate cancer, for analysis. Primary outcomes were treatment choice and health-related quality of life (HRQOL) assessed by the 26-item Expanded Prostate Index Composite (EPIC-26) at pre-specified intervals up to 5 years. Multivariable analysis was performed, controlling for demographic and clinicopathologic features.

Results: Median baseline PV was 36 mL (IQR 27-48), and baseline urinary irritative/obstructive domain score was 87 (IQR 75-100). There was no observed clinically meaningful association between PV and treatment choice or post-treatment urinary function. Among patients with poor baseline urinary function, treatment with radiation or surgery was associated with statistically and clinically significant improvement in urinary function at 6 months which was durable through 5 years (improvement from baseline at 5 years: radiation 20.4 points, surgery 24.5 points).

Conclusions: PV was not found to be associated with treatment modality or post-treatment urinary irritative/obstructive function among men treated for localized prostate cancer. Men with poor baseline urinary irritative/obstructive function improve after treatment with surgery or radiation therapy.

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Conflict of interest statement

Conflict of Interest: The authors have no relevant conflicts of interest to report.

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Sibona M, Destefanis P, Vercelli E, Secco S, Gontero P, Cindolo L. Sibona M, et al. Prostate Cancer Prostatic Dis. 2023 Sep;26(3):475-482. doi: 10.1038/s41391-023-00686-y. Epub 2023 Jul 27. Prostate Cancer Prostatic Dis. 2023. PMID: 37500787 Review.

References

1. Bostwick DG, Cooner WH, Denis L, Jones GW, Scardino PT, Murphy GP. The association of benign prostatic hyperplasia and cancer of the prostate. Cancer 1992; 70: 291–301. - PubMed
1. Sanda MG, Cadeddu JA, Kirkby E, Chen RC, Crispino T, Fontanarosa J et al. Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part II: Recommended Approaches and Details of Specific Care Options. J Urol 2018; 199: 990–997. - PubMed
1. Eastham JA, Auffenberg GB, Barocas DA, Chou R, Crispino T, Davis JW et al. Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, Part I: Introduction, Risk Assessment, Staging and Risk-Based Management. J Urol 2022; : 101097JU0000000000002757. - PubMed
1. Barocas DA, Penson DF. Functional Recovery Following Primary Treatment for Prostate Cancer: Update from the CEASAR Study. Eur Urol Focus 2020; 6: 205–207. - PubMed
1. Mendenhall NP, Rausch Osian SM, Bryant CM, Hoppe BS, Morris CG. What men want: Results from a national survey on decision making for prostate cancer treatment and research participation. Clin Transl Sci 2021; : cts.13090. - PMC - PubMed

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[1] Bostwick DG, Cooner WH, Denis L, Jones GW, Scardino PT, Murphy GP. The association of benign prostatic hyperplasia and cancer of the prostate. Cancer 1992; 70: 291–301. - PubMed

[2] Bostwick DG, Cooner WH, Denis L, Jones GW, Scardino PT, Murphy GP. The association of benign prostatic hyperplasia and cancer of the prostate. Cancer 1992; 70: 291–301. - PubMed

[3] Sanda MG, Cadeddu JA, Kirkby E, Chen RC, Crispino T, Fontanarosa J et al. Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part II: Recommended Approaches and Details of Specific Care Options. J Urol 2018; 199: 990–997. - PubMed

[4] Sanda MG, Cadeddu JA, Kirkby E, Chen RC, Crispino T, Fontanarosa J et al. Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part II: Recommended Approaches and Details of Specific Care Options. J Urol 2018; 199: 990–997. - PubMed

[5] Eastham JA, Auffenberg GB, Barocas DA, Chou R, Crispino T, Davis JW et al. Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, Part I: Introduction, Risk Assessment, Staging and Risk-Based Management. J Urol 2022; : 101097JU0000000000002757. - PubMed

[6] Eastham JA, Auffenberg GB, Barocas DA, Chou R, Crispino T, Davis JW et al. Clinically Localized Prostate Cancer: AUA/ASTRO Guideline, Part I: Introduction, Risk Assessment, Staging and Risk-Based Management. J Urol 2022; : 101097JU0000000000002757. - PubMed

[7] Barocas DA, Penson DF. Functional Recovery Following Primary Treatment for Prostate Cancer: Update from the CEASAR Study. Eur Urol Focus 2020; 6: 205–207. - PubMed

[8] Barocas DA, Penson DF. Functional Recovery Following Primary Treatment for Prostate Cancer: Update from the CEASAR Study. Eur Urol Focus 2020; 6: 205–207. - PubMed

[9] Mendenhall NP, Rausch Osian SM, Bryant CM, Hoppe BS, Morris CG. What men want: Results from a national survey on decision making for prostate cancer treatment and research participation. Clin Transl Sci 2021; : cts.13090. - PMC - PubMed

[10] Mendenhall NP, Rausch Osian SM, Bryant CM, Hoppe BS, Morris CG. What men want: Results from a national survey on decision making for prostate cancer treatment and research participation. Clin Transl Sci 2021; : cts.13090. - PMC - PubMed

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Prostate volume, baseline urinary function, and their association with treatment choice and post-treatment urinary function in men treated for localized prostate cancer

Affiliations

Prostate volume, baseline urinary function, and their association with treatment choice and post-treatment urinary function in men treated for localized prostate cancer

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Conflict of interest statement

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