Efficacy of hemoperfusion with Seraph-100 in series with single pass albumin dialysis in acute hepatitis B infection: A case report

Int J Artif Organs. 2023 Feb;46(2):81-84. doi: 10.1177/03913988221143142. Epub 2022 Dec 8.

Abstract

Acute and acute-on-chronic liver failure is a cause of death in patients suffering from viral hepatitis, and many cases need liver transplantation. Infection from hepatitis B virus may range from asymptomatic to severe acute and fulminant hepatitis. In this setting, treatment is mainly supportive as there is no consensus on antiviral therapy based on non-nucleoside reverse transcriptase inhibitors. Single-pass albumin dialysis is a liver-support technique for patients suffering from liver failure, that has shown effectiveness in the removal of both water-soluble and albumin-bound toxins, which accumulate due to impairment of the liver's cleansing function. We report here the case of a 62-year-old male who presented with a severe acute hepatitis B infection, liver failure, and marked hyperbilirubinemia. Treatment with single-pass albumin dialysis combined with a hemoperfusion device was successful in improving clinical, physiological, and laboratory parameters.

Keywords: Acute hepatitis B; Seraph 100 filter; albumin dialysis; hemoperfusion; liver failure.

Publication types

  • Case Reports

MeSH terms

  • Albumins
  • Hemoperfusion* / methods
  • Hepatitis B*
  • Humans
  • Liver Failure* / therapy
  • Male
  • Middle Aged
  • Renal Dialysis / methods

Substances

  • Albumins