A glimpse into TriC's magic chamber of secrets

Cell. 2022 Dec 8;185(25):4679-4681. doi: 10.1016/j.cell.2022.11.007.

Abstract

Chaperones are important for protein folding, but visualizing this process has proven to be exceptionally difficult. In this issue of Cell, Frydman and colleagues have succeeded in watching tubulin being folded by its chaperonin TRiC at near-atomic resolution.

MeSH terms

  • Chaperonin Containing TCP-1* / metabolism
  • Protein Folding*
  • Tubulin* / metabolism

Substances

  • Chaperonin Containing TCP-1
  • Tubulin