Mechanisms of circular RNA degradation

Commun Biol. 2022 Dec 9;5(1):1355. doi: 10.1038/s42003-022-04262-3.


Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. While the biogenesis and biological function of circRNAs have been extensively studied, there are few studies on circRNA degradation and only a few pathways for specific circRNA degradation have been identified. Here we outline basic information about circRNAs, summarize the research on the circRNA degradation mechanisms and discusses where this field might head, hoping to provide some inspiration and guidance for scholars who aim to study the degradation of circRNAs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • RNA Stability
  • RNA* / genetics
  • RNA* / metabolism
  • RNA, Circular* / genetics


  • RNA, Circular
  • RNA