Microbiota Composition in Diverticular Disease: Implications for Therapy

Int J Mol Sci. 2022 Nov 26;23(23):14799. doi: 10.3390/ijms232314799.


Gut microbiota (GM) composition and its imbalance are crucial in the pathogenesis of several diseases, mainly those affecting the gastrointestinal tract. Colon diverticulosis and its clinical manifestations (diverticular disease, DD) are among the most common digestive disorders in developed countries. In recent literature, the role of GM imbalance in the onset of the different manifestations within the clinical spectrum of DD has been highlighted. This narrative review aims to summarize and critically analyze the current knowledge on GM dysbiosis in diverticulosis and DD by comparing the available data with those found in inflammatory bowel disease (IBD). The rationale for using probiotics to rebalance dysbiosis in DD is also discussed.

Keywords: acute diverticulitis; diverticular disease; diverticulosis; gut microbiota; probiotics.

Publication types

  • Review

MeSH terms

  • Diverticular Diseases* / therapy
  • Dysbiosis / complications
  • Gastrointestinal Microbiome*
  • Humans
  • Inflammatory Bowel Diseases* / complications
  • Probiotics* / therapeutic use

Grants and funding

This research received no external funding.