1 School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
2 Perioperative and Critical Care Theme, National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, United Kingdom.
3 Department of Anesthesia, McGill University Health Center, Montreal, QC, Canada.
4 Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.