Ultra-high field neuroimaging in psychosis: A narrative review

Katie M Lavigne; Kesavi Kanagasabai; Lena Palaniyappan

doi:10.3389/fpsyt.2022.994372

Ultra-high field neuroimaging in psychosis: A narrative review

Front Psychiatry. 2022 Nov 24:13:994372. doi: 10.3389/fpsyt.2022.994372. eCollection 2022.

Authors

Katie M Lavigne^{1

2

3}, Kesavi Kanagasabai^{4

5}, Lena Palaniyappan^{1

3

4

5}

Affiliations

¹ Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
² Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada.
³ Department of Psychiatry, McGill University, Montreal, QC, Canada.
⁴ Robarts Research Institute, Western University, London, ON, Canada.
⁵ Department of Medical Biophysics, Western University, London, ON, Canada.

Abstract

Schizophrenia and related psychoses are complex neuropsychiatric diseases representing dysconnectivity across multiple scales, through the micro (cellular), meso (brain network), manifest (behavioral), and social (interpersonal) levels. In vivo human neuroimaging, particularly at ultra-high field (UHF), offers unprecedented opportunity to examine multiscale dysconnectivity in psychosis. In this review, we provide an overview of the literature to date on UHF in psychosis, focusing on microscale findings from magnetic resonance spectroscopy (MRS), mesoscale studies on structural and functional magnetic resonance imaging (fMRI), and multiscale studies assessing multiple neuroimaging modalities and relating UHF findings to behavior. We highlight key insights and considerations from multiscale and longitudinal studies and provide recommendations for future research on UHF neuroimaging in psychosis.

Keywords: 7 tesla; magnetic resonance imaging; magnetic resonance spectroscopy; multiscale; psychosis; schizophrenia; ultra-high field neuroimaging.

Publication types

Review