CatSper Calcium Channels: 20 Years On

Physiology (Bethesda). 2023 May 1;38(3):0. doi: 10.1152/physiol.00028.2022. Epub 2022 Dec 13.


The flagellar-specific Ca2+ channel CatSper is the predominant Ca2+ entry site in mammalian sperm. CatSper-mediated Ca2+ signaling affects nearly every event that regulates sperm to acquire fertilizing capability. In this review, we summarize some of the main findings from 20 years of CatSper research and highlight recent progress and prospects.

Keywords: CatSper; calcium signaling; fertilization; ion channel; sperm.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Channels* / metabolism
  • Calcium Signaling
  • Humans
  • Male
  • Mammals
  • Semen* / metabolism
  • Spermatozoa / metabolism


  • Calcium Channels
  • Calcium