Factors influencing the incidence and severity of swine-serum-induced bile duct lesion in mice

Br J Exp Pathol. 1987 Aug;68(4):511-20.


The detailed histopathology of the swine-serum (SS)-induced bile duct lesion and some factors influencing the incidence and severity of the lesion were examined. The lesion was expressed as an eosinophilic and proliferative cholangitis affecting almost the full length of the biliary tract. It appears to be a useful new model of bile duct diseases. The co-existence of sufficient anti-SS antibody together with repeated injection of SS were necessary to produce this lesion. The lesion could be induced reproducibly by intraperitoneal injection of 0.05 to 0.2 ml of swine serum twice a week for 4 weeks in young BALB/c mice.

MeSH terms

  • Animals
  • Bile Duct Diseases / etiology*
  • Bile Duct Diseases / pathology
  • Bile Ducts, Intrahepatic / pathology
  • Blood*
  • Cholangitis / etiology
  • Cholangitis / pathology
  • Common Bile Duct / pathology
  • Disease Models, Animal
  • Female
  • Hot Temperature
  • Immunization
  • Immunoglobulin G / biosynthesis
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Swine
  • Time Factors


  • Immunoglobulin G