Helicobacter pylori and Inflammatory Bowel Disease: An Unresolved Enigma

Inflamm Bowel Dis. 2023 Mar 1;29(3):e5-e6. doi: 10.1093/ibd/izac248.
No abstract available

Keywords: Helicobacter pylori; 2)-fucosyltransferase 2 (FUT2) gene; Crohn’s disease; inflammatory bowel disease; mucin glycan fucosylation; ulcerative colitis; α(1.

Plain language summary

The article describes the hypothesis that there may be a noncausal relationship between Helicobacter pylori infection and inflammatory bowel disease (IBD) that is related to the host mucin glycan fucosylation status in the gastrointestinal tract. The proposed hypothesis may explain why IBD is less prevalent in patients with H. pylori, and no increased risk of IBD is seen after H. pylori eradication therapy, as was shown in the study by Tanner et al.

Publication types

  • Letter
  • Comment

MeSH terms

  • Colitis, Ulcerative*
  • Helicobacter Infections*
  • Helicobacter pylori*
  • Humans
  • Inflammatory Bowel Diseases*