The microbiota control the neonatal WNT-ernet

Alex C McPherson; Marlies Meisel

doi:10.1016/j.immuni.2022.11.005

The microbiota control the neonatal WNT-ernet

Immunity. 2022 Dec 13;55(12):2219-2222. doi: 10.1016/j.immuni.2022.11.005.

Authors

Alex C McPherson¹, Marlies Meisel²

Affiliations

¹ Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
² Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: marlies@pitt.edu.

Abstract

The microbiome plays a fundamental role in maintaining intestinal stem cell (ISC)-niche equilibrium. In this issue of Immunity, Kim and colleagues uncover a mechanism by which the microbiota drives macrophage WNT ligand-release to maintain ISC-niche homeostasis during early postnatal development.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Infant, Newborn
Intestinal Mucosa
Microbiota* / physiology
Stem Cell Niche*
Wnt Signaling Pathway*

Abstract

Publication types

MeSH terms

Grants and funding