Serum Uromodulin Is a Possible Auxiliary Diagnostic Tool for Acute Tubular Injury and Acute Interstitial Nephritis: A Case Series

Ryosuke Usui; Tetsuya Ogawa; Chihiro Iwasaki; Kosaku Nitta; Minako Koike

doi:10.1159/000523855

Serum Uromodulin Is a Possible Auxiliary Diagnostic Tool for Acute Tubular Injury and Acute Interstitial Nephritis: A Case Series

Case Rep Nephrol Dial. 2022 Oct 11;12(3):185-192. doi: 10.1159/000523855. eCollection 2022 Sep-Dec.

Authors

Ryosuke Usui¹, Tetsuya Ogawa², Chihiro Iwasaki¹, Kosaku Nitta³, Minako Koike¹

Affiliations

¹ aDivision of Nephrology, Department of Medicine, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan.
² bDepartment of Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
³ cDepartment of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

Abstract

Recently, the usefulness of serum uromodulin (sUmod) as a novel renal biomarker has been attracting attention. Clinical evidence regarding sUmod measurements has been accumulated by analyzing cross-sectional data. However, little is known about the longitudinal data on sUmod. Therefore, we decided to investigate the variability of sUmod in patients with acute kidney injury due to different causes. High concentrations of sUmod have been observed in patients with acute tubular injury (ATI) and/or acute interstitial nephritis (AIN). sUmod could be used as an auxiliary diagnostic tool for ATI and AIN.

Keywords: Acute interstitial nephritis; Acute kidney injury; Acute tubular injury; Biomarker; Uromodulin.

Publication types

Case Reports