Plasma bisphenol a and phthalate levels in children with cerebral palsy: a case-control study

Int J Environ Health Res. 2024 Jan;34(1):499-513. doi: 10.1080/09603123.2022.2153811. Epub 2022 Dec 15.

Abstract

The case-control study aimed to evaluate potential sources of exposure and the plasma concentrations of bisphenol A (BPA) and phthalates in prepubertal children having cerebral palsy (CP) and healthy control. Blood samples of 68 CP and 70 controls were analyzed for BPA, di-(2-ethylhexyl)-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and dibutyl phthalate (DBP). BPA and DBP levels were similar in groups. The median DEHP and MEHP levels of the children with CP were significantly lower than those of the controls (p = 0.035, p < 0.001, respectively). Exposure to plastic food containers/bags, personal care hygiene products, household cleaners, wood/coal stove heating, and city water supplies were associated with increased odds of higher BPA and phthalate levels in children with CP. In conclusion, potential exposure sources for BPA and phthalates differ in children with CP and healthy controls, and children with CP are not exposed to higher levels of BPA and phthalates.

Keywords: BPA; Cerebral palsy; children; phthalate.

MeSH terms

  • Benzhydryl Compounds / analysis
  • Case-Control Studies
  • Cerebral Palsy*
  • Child
  • Cosmetics*
  • Dibutyl Phthalate
  • Diethylhexyl Phthalate*
  • Environmental Exposure / analysis
  • Humans
  • Phenols*
  • Phthalic Acids*

Substances

  • phthalic acid
  • mono-(2-ethylhexyl)phthalate
  • Diethylhexyl Phthalate
  • bisphenol A
  • Phthalic Acids
  • Benzhydryl Compounds
  • Dibutyl Phthalate
  • Cosmetics
  • Phenols