Non-obstructive jaundice as paraneoplastic syndrome of prostate carcinoma: Systematic review of published cases

Med Clin (Barc). 2023 Mar 10;160(5):206-212. doi: 10.1016/j.medcli.2022.11.001. Epub 2022 Dec 14.
[Article in English, Spanish]


Stauffer syndrome is a paraneoplastic syndrome (PS) that involves liver disorders; it has been often related to renal tumors, but also to others such as adenocarcinoma of the prostate (ACP). Our objective was to carry out a systematic review of published cases associated with ACP. A total of 357 articles were accessed, 25 of which met the study's inclusion criteria. All published cases of Stauffer syndrome in patients diagnoses with ACP were in the metastatic stage. The PS resolved in 3 out of 4 patients when ACP-targeted therapy was implemented. The following were identified as poor prognosis factors: the diagnosis of ACP prior to that of SP, non-elevated levels of total bilirubin, and the non-resolution of SP at the start of treatment.

Keywords: Adenocarcinoma de próstata; Paraneoplastic syndrome; Prostate adenocarcinoma; Stauffer syndrome; Síndrome de Stauffer; Síndrome paraneoplásico.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Carcinoma*
  • Humans
  • Jaundice* / complications
  • Kidney Neoplasms* / complications
  • Male
  • Paraneoplastic Syndromes* / diagnosis
  • Paraneoplastic Syndromes* / etiology
  • Prostate / pathology
  • Prostatic Neoplasms* / complications
  • Prostatic Neoplasms* / diagnosis
  • Prostatic Neoplasms* / pathology