Autonomic dysfunction in severe tetanus: magnesium sulfate as an adjunct to deep sedation

Crit Care Med. 1987 Oct;15(10):987-8.


We studied the use of continuous iv magnesium (Mg) infusion to control the sympathetic crises in a patient with severe tetanus characterized by pronounced autonomic nervous system instability. Our results suggested that Mg is a useful adjunct to the CNS depressants traditionally used. This therapy controlled the sympathetic crises and also suppressed the release of catecholamines, although Mg infusions alone appeared to be inadequate therapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Pressure
  • Diazepam / therapeutic use
  • Epinephrine / blood
  • Humans
  • Infusions, Intravenous
  • Magnesium Sulfate / therapeutic use*
  • Male
  • Norepinephrine / blood
  • Tetanus / drug therapy*
  • Tetanus / physiopathology


  • Magnesium Sulfate
  • Diazepam
  • Norepinephrine
  • Epinephrine