Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene

DNA. 1987 Aug;6(4):283-95. doi: 10.1089/dna.1987.6.283.

Abstract

Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5'-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Fetus / physiology
  • Gene Expression Regulation
  • Humans
  • Insulin-Like Growth Factor II / genetics*
  • Molecular Sequence Data
  • Neoplasms / genetics
  • Promoter Regions, Genetic
  • RNA Splicing
  • RNA, Messenger / genetics
  • Rats
  • Repetitive Sequences, Nucleic Acid
  • Somatomedins / genetics*
  • Tissue Distribution
  • Transcription, Genetic

Substances

  • RNA, Messenger
  • Somatomedins
  • Insulin-Like Growth Factor II

Associated data

  • GENBANK/M17285
  • GENBANK/M22372
  • GENBANK/M22373