Gut microbiota in ischemic stroke: Where we stand and challenges ahead

Jiaxin Long; Jinlong Wang; Yang Li; Shuai Chen

doi:10.3389/fnut.2022.1008514

Gut microbiota in ischemic stroke: Where we stand and challenges ahead

Front Nutr. 2022 Dec 1:9:1008514. doi: 10.3389/fnut.2022.1008514. eCollection 2022.

Authors

Jiaxin Long^{1

2}, Jinlong Wang¹, Yang Li¹, Shuai Chen¹

Affiliations

¹ Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
² College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.

Abstract

Gut microbiota is increasingly recognized to affect host health and disease, including ischemic stroke (IS). Here, we systematically review the current understanding linking gut microbiota as well as the associated metabolites to the pathogenesis of IS (e.g., oxidative stress, apoptosis, and neuroinflammation). Of relevance, we highlight that the implications of gut microbiota-dependent intervention could be harnessed in orchestrating IS.

Keywords: apoptosis; gut microbiota; inflammation; ischemic stroke; microbial metabolites; oxidative stress.

Publication types

Review