T lymphocyte-mediated pyroptosis: A new regulatory mechanism in non-viral liver disease

Abstract

T lymphocyte-mediated pyroptosis plays an important role in the development of non-viral liver diseases. Pyroptosis as a programmed cell death process, has been a hot topic of research on disease pathogenesis in recent years. As one of the most common immune cells in the body, T cells are the major players in adaptive immunity. An increasing number of studies have shown that T lymphocyte-mediated pyroptosis functions in non-viral liver diseases to regulate immune function, alter the immune microenvironment, and thus influence disease progression. These findings will guide us and provide new ideas for the development of subsequent therapeutic agents for non-viral liver diseases.

Keywords: Alcoholic liver disease; Autoimmune liver disease; Non-viral liver disease; Nonalcoholic fatty liver disease; Pyroptosis; T-lymphocyte.