A new unstable and low oxygen affinity hemoglobin variant: Hb J-Auckland [beta 25(B7)Gly----Asp]

Hemoglobin. 1987;11(3):221-30. doi: 10.3109/03630268709017888.

Abstract

Hb J-Auckland is a new hemoglobin variant with the amino acid substitution beta 25(B7)Gly----Asp. It is mildly unstable and has a low oxygen affinity. The propositus and a son, both heterozygous for Hb J-Auckland, have marginally low Hb values but no apparent clinical symptoms.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Aspartic Acid / metabolism
  • Drug Combinations / metabolism
  • Glycine / metabolism
  • Hemoglobin J / genetics
  • Hemoglobin J / isolation & purification*
  • Hemoglobin J / metabolism
  • Hemoglobins, Abnormal / genetics
  • Hemoglobins, Abnormal / isolation & purification*
  • Hemoglobins, Abnormal / metabolism
  • Humans
  • Male
  • Middle Aged
  • Oxygen / metabolism*
  • Peptide Fragments
  • Peptide Mapping

Substances

  • Drug Combinations
  • Hemoglobins, Abnormal
  • Peptide Fragments
  • hemoglobin J Auckland
  • Aspartic Acid
  • Hemoglobin J
  • Oxygen
  • Glycine