Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma

Xiaofeng Ding; Chen Zhang; Huajian Chen; Minghua Ren; Xiaodong Liu

doi:10.3390/cells11244108

Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma

Cells. 2022 Dec 17;11(24):4108. doi: 10.3390/cells11244108.

Authors

Xiaofeng Ding^{1

2}, Chen Zhang¹, Huajian Chen^{1

3}, Minghua Ren⁴, Xiaodong Liu^{1

2

3}

Affiliations

¹ School of Public Health and Management, Wenzhou Medical University, Wenzhou 325035, China.
² South Zhejiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou 325800, China.
³ Key Laboratory of Watershed Science and Health of Zhejiang Province, Wenzhou Medical University, Wenzhou 325035, China.
⁴ Department of Urinary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Abstract

Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM. We analyzed cathepsins (cathepsin B, cathepsin D, cathepsin L, and cathepsin Z/X), which are highly associated with the radioresistance of GBM by regulating different types of cell death. Cathepsins could be potential targets for GBM treatment.

Keywords: cathepsins; cell death; glioblastoma; radiosensitivity; radiotherapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms* / genetics
Brain Neoplasms* / metabolism
Brain Neoplasms* / radiotherapy
Cell Death
Glioblastoma* / metabolism
Glioblastoma* / radiotherapy
Humans

Grants and funding

This work was supported by the National Natural Science Foundation of China (81972969, 81872558, 81773363, and 81673092).