Health-Related Quality of Life (HRQOL) Instruments and Mobility: A Systematic Review

Int J Environ Res Public Health. 2022 Dec 8;19(24):16493. doi: 10.3390/ijerph192416493.


Physical function is one of the most important constructs assessed in health-related quality of life (HRQOL), and it could be very useful to assess movement ability from the perspective of the patient. The objective of this study was to compare the content of the domains related to mobility covered by the HRQOL questionnaires based on the International Classification of Functioning, Disability and Health (ICF) and to evaluate their quality according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidance. For this, a systematic review was carried out in the databases Scopus, Web of Science and Science Direct. The inclusion criteria were development and/or validation studies about generic HRQOL measures, and the instruments had to include items related to mobility and studies written in English or Spanish. The comparison of content was performed using the ICF coding system. A total of 3614 articles were found, 20 generic HRQOL instruments were identified and 120 (22.4%) mobility-related items were found. Walking was the most represented category. Low-quality evidence on some measurement properties of the generic HRQOL instruments was revealed. The CAT-Health is a useful questionnaire to be used in rehabilitation due to its psychometric properties and its content.

Keywords: Disability and Health (ICF); International Classification of Functioning; generic instruments; measurement instruments; mobility; movement; quality of life.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Activities of Daily Living
  • Disabled Persons* / rehabilitation
  • Humans
  • Psychometrics
  • Quality of Life*
  • Surveys and Questionnaires
  • Walking

Grants and funding

This research received no external funding.