Association between the geriatric nutritional risk index and the risk of stroke in elderly patients with hypertension: A longitudinal and cohort study

Xintian Cai; Junli Hu; Wen Wen; Mengru Wang; Qing Zhu; Shasha Liu; Wenbo Yang; Yujie Dang; Jing Hong; Nanfang Li

doi:10.3389/fnut.2022.1048206

Association between the geriatric nutritional risk index and the risk of stroke in elderly patients with hypertension: A longitudinal and cohort study

Front Nutr. 2022 Dec 6:9:1048206. doi: 10.3389/fnut.2022.1048206. eCollection 2022.

Authors

Xintian Cai¹, Junli Hu¹, Wen Wen¹, Mengru Wang¹, Qing Zhu¹, Shasha Liu¹, Wenbo Yang¹, Yujie Dang¹, Jing Hong¹, Nanfang Li¹

Affiliation

¹ Hypertension Center, Xinjiang Hypertension Institute, NHC Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Medical Research Center for Hypertension Diseases, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.

Abstract

Objective: We aimed to investigate the association between the GNRI and the risk of stroke in elderly patients with hypertension.

Methods: A total of 5312 elderly hypertensive patients free of history of stroke were included. Multivariate Cox models were used to calculate hazard ratios (HRs) and their 95% confidence intervals (CIs) for stroke and its subtypes.

Results: The average time of follow-up was 3.8 years, and the median time was 3.2 years. We identified 640 individuals with stroke, of whom 526 had an ischemic stroke (IS) and 114 had a hemorrhagic stroke (HS). After adjusting for confounding variables, compared with participants in the lowest quartile of the GNRI, those in the third and fourth quartiles were associated with a decreased risk of stroke (adjusted HR 0.72, 95% CI 0.58-0.90, and adjusted HR 0.58, 95% CI 0.46-0.74, respectively, P for trend < 0.001). Similar results were found for IS and HS. Moreover, there were L-shaped associations of GNRI with new-onset HS (P for non-linearity = 0.034). Multiple sensitivity analyses and stratified analyses did not materially change the results.

Conclusions: In summary, we found that a lower GNRI was associated with a higher risk of incident stroke in elderly hypertensive patients. Additional prospective data collection is required to confirm our findings.

Keywords: elderly; geriatric nutritional risk index; hypertension; longitudinal cohort; stroke.