Use of infrared photobiomodulation with low-level laser therapy for reduction of bleaching-induced tooth sensitivity after in-office bleaching: a double-blind, randomized controlled trial

Lasers Med Sci. 2022 Dec 23;38(1):18. doi: 10.1007/s10103-022-03682-1.


The purpose of this study is to evaluate the use of infrared photobiomodulation with low-level laser therapy (PBM) to reduce bleaching-induced tooth sensitivity (TS) after in-office bleaching. Eighty-three participants were randomized in blocks into two groups. In the experimental group, the patients received an application after each session of in-office bleaching (35% hydrogen peroxide, 1 × 50 min; 2 sessions with 1-week interval), while the laser application was simulated in the control group. The PBM system was operated in continuous mode, using 3 J of energy. A dose of 100 J/cm2 was applied for 30 s with 808 nm (100 mW of power) in the middle third of the crown. The risk and intensity of TS were recorded immediately after bleaching, 1 h, 24 h, and 48 h after each bleaching session, with a visual scale analog (0-10) and a five-point numerical scale (0-4). The color was recorded at the beginning, weekly, and 1 month after the end of the bleaching (VITA Classical, VITA Bleachedguide, and digital spectrophotometer). The risk of TS was 98% (95% CI 88 to 99%) for the laser group and 95% (95% CI 83 to 99%) for the control (RR = 1.03; 95% CI 0.94 to 1.12; p = 1.0). Similarly, no difference in the intensity of TS was detected for both pain scales (p > 0.65). Improvement in color change, regardless of the group, was observed (p > 0.15). The application of an PBM did not reduce the risk and intensity of TS when applied after the procedure using the parameters recommended by the manufacturer.Trial registration number and date of registration: RBR-4HCVSG-04/06/2019.

Keywords: Dentin sensitivity; Low-level light therapy; Photobiomodulation; Tooth bleaching.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Dentin Sensitivity* / chemically induced
  • Dentin Sensitivity* / radiotherapy
  • Humans
  • Hydrogen Peroxide
  • Low-Level Light Therapy*
  • Tooth Bleaching Agents* / adverse effects
  • Tooth Bleaching* / adverse effects
  • Tooth Bleaching* / methods
  • Treatment Outcome


  • Tooth Bleaching Agents
  • Hydrogen Peroxide