Role of miRNAs interference on ovarian functions and premature ovarian failure

Cell Commun Signal. 2022 Dec 23;20(1):198. doi: 10.1186/s12964-022-00992-3.


Premature ovarian failure is a to some extent unknown and intricate problem with diverse causes and clinical manifestations. The lack of ovarian sex hormones presumably is effective in the occurrence of ovarian failure. Our progress in this field has been very little despite undertaken scientific research endeavors; scholars still are trying to understand the explanation of this dilemmatic medical condition. In contrast, the practice of clinical medicine has made meaningful strides in providing assurance to the women with premature ovarian insufficiency that their quality of life as well as long-term health can be optimized through timely intervention. Very recently Scientists have investigated the regulating effects of small RNA molecules on steroidogenesis apoptosis, ovulation, gonadal, and corpus luteum development of ovaries. In this literature review, we tried to talk over the mechanisms of miRNAs in regulating gene expression after transcription in the ovary. Video abstract.

Keywords: Effective micro-RNA in ovary; Effective signaling in the ovary; Premature ovarian failure.

Publication types

  • Video-Audio Media
  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • MicroRNAs* / genetics
  • Ovulation / physiology
  • Primary Ovarian Insufficiency* / genetics
  • Quality of Life


  • MicroRNAs