Loss of control in preschoolers with asthma is a risk factor for disease persistency

Acta Paediatr. 2023 Mar;112(3):496-504. doi: 10.1111/apa.16630. Epub 2022 Dec 24.


Aim: To describe the relationship between loss of control events in preschoolers with asthma and persistence of disease.

Methods: We reviewed medical records of children <6 years diagnosed with asthma in 2018 to assess loss of control events during three years of follow-up. Asthma persistency was defined by redeem of short-acting β2-agonist or asthma controllers within one year after the end of follow-up. Logistic regression models were applied to analyse the association between loss of control events and persistence of asthma.

Results: We included 172 patients (median age 1.8 years), whereof 126 (73.3%) experienced a loss of control event and 87 (50.6%) had asthma one year after the end of follow-up. Any loss of control event was associated with persistence of asthma adjusted for controller treatment at inclusion, prior exacerbations, atopic comorbidity and caesarean section: aOR, 10.9 (95% CI, 3.9-34.6), p < 0.001. This was also significant restricted to events in the first year of follow-up: 3.52 (1.50-8.67), p < 0.01 and among children only experiencing one event: 6.4 (1.7-27.3), p = 0.01.

Conclusion: Loss of control events during a 3-year period among preschoolers with asthma are closely related to disease persistency, which may aid clinicians to assess risk of persistent asthma in young children.

Keywords: asthma; children; loss of control; persistence; remission.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Anti-Asthmatic Agents* / therapeutic use
  • Asthma* / drug therapy
  • Cesarean Section
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Pregnancy
  • Risk Factors


  • Adrenal Cortex Hormones
  • Anti-Asthmatic Agents