Evaluation of antiviral activity of terpenophenols and some of their N- and O-derivatives

I Yu Chukicheva; E V Buravlev; I A Dvornikova; I V Fedorova; V V Zarubaev; A V Slita; Ya L Esaulkova; A V Kutchin

doi:10.1007/s11172-022-3676-y

Evaluation of antiviral activity of terpenophenols and some of their N- and O-derivatives

Russ Chem Bull. 2022;71(11):2473-2481. doi: 10.1007/s11172-022-3676-y. Epub 2022 Dec 19.

Authors

I Yu Chukicheva¹, E V Buravlev¹, I A Dvornikova¹, I V Fedorova¹, V V Zarubaev², A V Slita², Ya L Esaulkova², A V Kutchin¹

Affiliations

¹ Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomayskaya, 167000 Syktyvkar, Russian Federation.
² St. Petersburg Pasteur Institute, 14 ul. Mira, 197101, St. Petersburg, Russian Federation.

Abstract

A comparative evaluation of the antiviral activity of a number of new and previously synthesized terpenophenols and their N- or O-containing derivatives against the A/Puerto Rico/8/34 (H1N1) virus strain was carried out. 2-Isobornylphenol, 1,2-dihydroxy-6-isobornyl-4-methylbenzene, 2-isobornyl-1,4-benzoquinone, and N-butyl-4-hydroxy-3,5-diisobornylbenzamide showed the highest activity.

Keywords: Mannich bases; antiviral activity; hydroxymethyl derivatives; terpenophenols.