Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury

J Exp Med. 2023 Mar 6;220(3):e20220615. doi: 10.1084/jem.20220615. Epub 2022 Dec 26.


Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically restricted plasticity and little functional recovery. In contrast, coordinated stimulation of both supraspinal centers and spinal relay stations resulted in marked and circuit-specific enhancement of neuronal rewiring, shortened EMG latencies, and improved locomotor recovery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Interneurons
  • Nerve Regeneration* / physiology
  • Neuronal Plasticity
  • Neurons / physiology
  • Recovery of Function / physiology
  • Spinal Cord
  • Spinal Cord Injuries* / therapy