A Cross-Sectional Study on the Relationship Between Rosacea Severity and Quality of Life or Psychological State

Fengjuan Yang; Qian Zhang; Deyu Song; Xu Liu; Lian Wang; Xian Jiang

doi:10.2147/CCID.S390921

A Cross-Sectional Study on the Relationship Between Rosacea Severity and Quality of Life or Psychological State

Clin Cosmet Investig Dermatol. 2022 Dec 20:15:2807-2816. doi: 10.2147/CCID.S390921. eCollection 2022.

Authors

Fengjuan Yang¹, Qian Zhang¹, Deyu Song¹, Xu Liu¹, Lian Wang¹, Xian Jiang^{1

2}

Affiliations

¹ Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
² Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Abstract

Background: Rosacea appears predominantly in highly visible areas of the facial region.

Objective: To investigate the psychological status and quality of life(QOL) of rosacea.

Methods: We used a hospital-based cross-sectional analytical study design between Jan 1, 2020, and Jan 1, 2021. We analyzed the differences and correlations in the severity of rosacea and its impacts on QOL and mental health, separately.

Results: 469 patients with rosacea were included. The mean Dermatology Life Quality Index (DLQI) score was 12.6±7.7 and the affected level of DLQI was moderately severe. The total score of Rosacea-specific Quality-of-Life instrument (RosQol) was 2.34 ± 0.84, and the scores of emotion, symptoms, and function were 2.41 ± 0.99, 2.37 ±0.82, and 2.03 ± 0.89, respectively. 44.8% of patients suffered from anxiety and 37.5% from depression. There were statistically significant differences in the incidence of anxiety (p <0.001), the DLQL (p =0.02), RosQol emotion (p =0.04), symptom (p <0.01) and function (p =0.02) scores in the different severity. In addition, worsening QOL was significantly associated with increased disease severity [Spearman's rank correlation index (r) ranging from 0.171 to 0.266,p<0.01 (RosQol); r =0.104,p =0.024 (DLQI)]. There was also a positive correlation between anxiety [r =0.155; p<0.01] and the different severity levels.

Conclusion: Rosacea maybe has a greater significant impact on patient's QOL and mental health. And the impact of QOL and mental health tend to deteriorate significantly with increasing disease severity. The relationship suggests that QOL assessment is of great interest in clinical practice and should be further explored.

Keywords: anxiety; depression; quality of life; rosacea; severity.

Grants and funding

This study was supported by Clinical Research Innovation Project, West China Hospital, Sichuan University (grant no.19HXCX010) and the National Natural Science Foundation of China (grant no.82273559).