Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists

Hongmin Cai; Youwei Xu; Shimeng Guo; Xinheng He; Jun Sun; Xin Li; Changyao Li; Wanchao Yin; Xi Cheng; Hualiang Jiang; H Eric Xu; Xin Xie; Yi Jiang

doi:10.1038/s41421-022-00503-1

Structures of adenosine receptor A_2BR bound to endogenous and synthetic agonists

Cell Discov. 2022 Dec 28;8(1):140. doi: 10.1038/s41421-022-00503-1.

Authors

Hongmin Cai^#¹, Youwei Xu^#¹, Shimeng Guo^#², Xinheng He^{1

3}, Jun Sun^{2

3}, Xin Li^{2

3}, Changyao Li^{1

3}, Wanchao Yin^{1

3

4}, Xi Cheng^{1

3

5}, Hualiang Jiang^{1

3

5

6

7}, H Eric Xu^{8

9

10

11}, Xin Xie^{12

13

14

15

16}, Yi Jiang^{17

18}

Affiliations

¹ CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
² CAS Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
³ University of Chinese Academy of Sciences, Beijing, China.
⁴ Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, Guangdong, China.
⁵ School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
⁶ School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
⁷ Lingang Laboratory, Shanghai, China.
⁸ CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.
⁹ University of Chinese Academy of Sciences, Beijing, China. eric.xu@simm.ac.cn.
¹⁰ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. eric.xu@simm.ac.cn.
¹¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.
¹² CAS Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. xxie@simm.ac.cn.
¹³ University of Chinese Academy of Sciences, Beijing, China. xxie@simm.ac.cn.
¹⁴ School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China. xxie@simm.ac.cn.
¹⁵ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. xxie@simm.ac.cn.
¹⁶ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. xxie@simm.ac.cn.
¹⁷ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. yjiang@lglab.ac.cn.
¹⁸ Lingang Laboratory, Shanghai, China. yjiang@lglab.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter