A new diterpenoid from Salvia santolinifolia boiss

Nat Prod Res. 2022 Dec 28;1-7. doi: 10.1080/14786419.2022.2161538. Online ahead of print.


Phytochemical study of the Salvia santolinifolia root extract resulted in the isolation of one new quinone diterpenoid, aegyptinone E (1) as well as two known ones, aegyptinone A (2) and aegyptinone D (3). All the isolated compounds were reported for the first time from S. santolinifolia. Spectroscopic analyses including 1 D and 2 D NMR and HRESIMS were used to determine the chemical structures. Aegyptinone A (2) showed moderate antibacterial activity against Staphylococcus aureus, Staphylococcus epidermis, and Bacillus subtilis with MIC of 25 μg/mL.

Keywords: Lamiaceae; Quinone diterpenoids; Salvia; antibacterial activity.