Habitual intakes of sugar-sweetened beverages associated with gut microbiota-related metabolites and metabolic health outcomes in young Chinese adults

doi:10.1016/j.numecd.2022.10.016

. 2023 Feb;33(2):359-368.

doi: 10.1016/j.numecd.2022.10.016. Epub 2022 Nov 3.

Habitual intakes of sugar-sweetened beverages associated with gut microbiota-related metabolites and metabolic health outcomes in young Chinese adults

Tao Yan¹, Lin Shi², Kun Xu³, Jinyu Bai¹, Ruixue Wen¹, Xia Liao⁴, Xiaoshuang Dai⁵, Qian Wu³, Lingxia Zeng³, Wen Peng⁶, Youfa Wang⁷, Hong Yan³, Shaonong Dang⁸, Xin Liu⁹

Affiliations

¹ School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi' an, Shaanxi, China.
² School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi' an, Shaanxi, China; Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. Electronic address: linshi198808@snnu.edu.cn.
³ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
⁴ Department of Nutrition, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
⁵ BGI Institute of Applied Agriculture, BGI-Agro, Shenzhen, China.
⁶ Nutrition and Health Promotion Center, Department of Public Health, Medical College, Qinghai University, Xining, Qinghai, China.
⁷ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
⁸ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. Electronic address: tjdshn@xjtu.edu.cn.
⁹ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. Electronic address: xinliu@xjtu.edu.cn.

PMID: 36577637
DOI: 10.1016/j.numecd.2022.10.016

Habitual intakes of sugar-sweetened beverages associated with gut microbiota-related metabolites and metabolic health outcomes in young Chinese adults

Tao Yan et al. Nutr Metab Cardiovasc Dis. 2023 Feb.

. 2023 Feb;33(2):359-368.

doi: 10.1016/j.numecd.2022.10.016. Epub 2022 Nov 3.

Authors

Tao Yan¹, Lin Shi², Kun Xu³, Jinyu Bai¹, Ruixue Wen¹, Xia Liao⁴, Xiaoshuang Dai⁵, Qian Wu³, Lingxia Zeng³, Wen Peng⁶, Youfa Wang⁷, Hong Yan³, Shaonong Dang⁸, Xin Liu⁹

Affiliations

¹ School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi' an, Shaanxi, China.
² School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi' an, Shaanxi, China; Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. Electronic address: linshi198808@snnu.edu.cn.
³ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
⁴ Department of Nutrition, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
⁵ BGI Institute of Applied Agriculture, BGI-Agro, Shenzhen, China.
⁶ Nutrition and Health Promotion Center, Department of Public Health, Medical College, Qinghai University, Xining, Qinghai, China.
⁷ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
⁸ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. Electronic address: tjdshn@xjtu.edu.cn.
⁹ Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. Electronic address: xinliu@xjtu.edu.cn.

PMID: 36577637
DOI: 10.1016/j.numecd.2022.10.016

Abstract

Background and aims: Reducing consumption of sugar-sweetened beverages (SSBs) is a global public health priority because of their limited nutritional value and associations with increased risk of obesity and metabolic diseases. Gut microbiota-related metabolites emerged as quintessential effectors that may mediate impacts of dietary exposures on the modulation of host commensal microbiome and physiological status.

Methods and results: This study assessed the associations among SSBs, circulating microbial metabolites, and gut microbiota-host co-metabolites, as well as metabolic health outcomes in young Chinese adults (n = 86), from the Carbohydrate Alternatives and Metabolic Phenotypes study in Shaanxi Province. Five principal component analysis-derived beverage drinking patterns were determined on self-reported SSB intakes, which were to a varying degree associated with 143 plasma levels of gut microbiota-related metabolites profiled by untargeted metabolomics. Moreover, carbonated beverages, fruit juice, energy drinks, and bubble tea exhibited positive associations with obesity-related markers and blood lipids, which were further validated in an independent cohort of 16,851 participants from the Regional Ethnic Cohort Study in Northwest China in Shaanxi Province. In contrast, presweetened coffee was negatively associated with the obesity-related traits. A total of 79 metabolites were associated with both SSBs and metabolic markers, particularly obesity markers. Pathway enrichment analysis identified the branched-chain amino acid catabolism and aminoacyl-tRNA biosynthesis as linking SSB intake with metabolic health outcomes.

Conclusion: Our findings demonstrate the associations between habitual intakes of SSBs and several metabolic markers relevant to noncommunicable diseases, and highlight the critical involvement of gut microbiota-related metabolites in mediating such associations.

Keywords: Gut microbiota; Metabolic health outcomes; Plasma metabolome; Sugar-sweetened beverage.

Copyright © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

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Conflict of interest statement

Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Habitual intakes of sugar-sweetened beverages associated with gut microbiota-related metabolites and metabolic health outcomes in young Chinese adults

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Habitual intakes of sugar-sweetened beverages associated with gut microbiota-related metabolites and metabolic health outcomes in young Chinese adults

Authors

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Abstract

Conflict of interest statement

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