Incidental diagnosis of a rare pancreatic plasmacytoma with plasmablastic features

Sabah Iqbal; Shubham Agrawal; Krishna Desai; Mahati Paravathaneni; Rajesh Thirumaran

doi:10.1080/08998280.2022.2132790

Incidental diagnosis of a rare pancreatic plasmacytoma with plasmablastic features

Proc (Bayl Univ Med Cent). 2022 Oct 19;36(1):85-86. doi: 10.1080/08998280.2022.2132790. eCollection 2023.

Authors

Sabah Iqbal¹, Shubham Agrawal¹, Krishna Desai¹, Mahati Paravathaneni², Rajesh Thirumaran³

Affiliations

¹ Department of Internal Medicine, Mercy Catholic Medical Center, Darby, Pennsylvania.
² Department of Hematology and Oncology, USF Morsani College of Medicine, Tampa, Florida.
³ Department of Hematology and Oncology, Mercy Catholic Medical Center, Darby, Pennsylvania.

Abstract

Multiple myeloma is a plasma cell neoplasm that accounts for 10% of all hematologic malignancies, characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. It predominantly affects men 60 to 70 years of age. Plasmacytoma is a discrete mass of neoplastic monoclonal plasma cells that may be osseous or extramedullary. Though extramedullary plasmacytomas are uncommon, they can involve any tissue or organ. Only a few cases of pancreatic involvement have been reported. We report a case of a 78-year-old woman with a long-standing history of multiple myeloma noted to have pancreatic tail involvement with plasmacytoma with plasmablastic features. Multiple myeloma with plasmablastic transformation has a poor prognosis; hence, a multidisciplinary team approach is crucial to identify and initiate appropriate management in these cases.

Keywords: Extramedullary multiple myeloma; multiple myeloma; pancreatic plasmacytoma; plasmablastic features.

Publication types

Case Reports