Injection of baclofen into the ventromedial hypothalamus stimulates gastric motility in the rat

Neuropharmacology. 1987 Aug;26(8):1191-4. doi: 10.1016/0028-3908(87)90267-x.

Abstract

Injection of 2 micrograms (+/-)-baclofen into the ventromedial hypothalamus (VMH) of urethane-anaesthetized rats resulted in an increase in gastric tone and amplitude of contractions. This effect was curtailed by administration of atropine methyl nitrate (20 mg/kg i.p.) or bilateral cervical vagotomy. These results provide evidence for a hypothalamic modulation of gastric motility by the vagus. Baclofen, possibly acting on receptors insensitive to gamma-aminobutyric acid (GABA), may be mimicking a vagal activation system, located within the ventro-medial hypothalamus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atropine / pharmacology
  • Baclofen / pharmacology*
  • Gastrointestinal Motility / drug effects*
  • Hypothalamus, Middle / drug effects*
  • Hypothalamus, Middle / metabolism
  • Male
  • Muscimol / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Vagotomy
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Muscimol
  • gamma-Aminobutyric Acid
  • Atropine
  • Baclofen