Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons

Neurosci Lett. 1987 Aug 31;79(3):301-5. doi: 10.1016/0304-3940(87)90448-4.

Abstract

The action of tetrahydro-9-aminoacridine (THA) on guinea pig pyramidal neurons was examined using intracellular recording in an in vitro hippocampal slice preparation. THA had a powerful excitatory action on pyramidal neurons, causing depolarization, increased firing, and an increase in input resistance. This excitatory action of THA persisted in atropine and in tetrodotoxin. The estimated reversal potential of this THA effect was near -90 mV. These results indicate that THA has a direct excitatory action on pyramidal neurons independent of its anticholinesterase activity, resulting from blockade of a conductance carried predominantly by potassium ions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Aminoacridines / pharmacology*
  • Animals
  • Atropine / pharmacology
  • Guinea Pigs
  • Hippocampus / drug effects*
  • Hippocampus / physiology
  • In Vitro Techniques
  • Male
  • Membrane Potentials / drug effects
  • Tacrine / pharmacology*
  • Tetrodotoxin / pharmacology

Substances

  • Aminoacridines
  • Tetrodotoxin
  • Tacrine
  • Atropine