Long-term vonoprazan administration causes gastric fundic gland-type hyperplastic polyps and chronic bleeding

Clin J Gastroenterol. 2023 Apr;16(2):159-163. doi: 10.1007/s12328-022-01751-0. Epub 2022 Dec 31.

Abstract

A patient experienced gastric fundic gland-type hyperplastic polyps, consisting of foveolar epithelium and parietal cells, complicated with chronic bleeding due to long-term treatment with vonoprazan. The patient had progressive anemia, probably caused by bleeding from the polyps. After switching from vonoprazan to a histamine-2 (H2) receptor antagonist, the polyps markedly shrank and the anemia improved. Vonoprazan can produce reversible hyperplastic polyps and anemia. In case of anemia in patients receiving long-term vonoprazan, it is important to consider drug cessation or change to an H2 blocker.

Keywords: Gastric polyp; PPI; Vonoprazan.

MeSH terms

  • Adenomatous Polyps*
  • Anemia*
  • Hemorrhage
  • Humans
  • Polyps* / chemically induced
  • Polyps* / complications
  • Stomach Neoplasms* / complications

Substances

  • 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine

Supplementary concepts

  • Polyposis, Gastric