Hypoxia-responsive nanomaterials for tumor imaging and therapy

Yifei Xia; Shao Duan; Chaozhe Han; Chengwei Jing; Zunyu Xiao; Chao Li

doi:10.3389/fonc.2022.1089446

Hypoxia-responsive nanomaterials for tumor imaging and therapy

Front Oncol. 2022 Dec 15:12:1089446. doi: 10.3389/fonc.2022.1089446. eCollection 2022.

Authors

Yifei Xia¹, Shao Duan¹, Chaozhe Han¹, Chengwei Jing¹, Zunyu Xiao², Chao Li¹

Affiliations

¹ Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
² Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin, China.

Abstract

Hypoxia is an important component of tumor microenvironment and plays a pivotal role in cancer progression. With the distinctive physiochemical properties and biological effects, various nanoparticles targeting hypoxia had raised great interest in cancer imaging, drug delivery, and gene therapy during the last decade. In the current review, we provided a comprehensive view on the latest progress of novel stimuli-responsive nanomaterials targeting hypoxia-tumor microenvironment (TME), and their applications in cancer diagnosis and therapy. Future prospect and challenges of nanomaterials are also discussed.

Keywords: cancer imaging; drug delivery; hypoxia tumor microenvironment; stimuli-responsive nanoparticle; tumor microenvironment targeted theranostics.

Publication types

Review