Abstract
Electric foot-shock increased DOPAC and decreased DA levels by about 70 and 20% respectively in the medial prefrontal cortex in rats. Pretreatment with diazepam (5 mg/kg IP) or ethanol (1.2 g/kg orally) prevented these stress-induced changes. The protective effect of diazepam and ethanol was eliminated by RO 15-4513 (5 mg/kg IP) a partial inverse benzodiazepine agonist.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
3,4-Dihydroxyphenylacetic Acid / metabolism*
-
Animals
-
Azides / pharmacology*
-
Benzodiazepines / pharmacology*
-
Diazepam / pharmacology
-
Electroshock
-
Ethanol / pharmacology*
-
Male
-
Phenylacetates / metabolism*
-
Rats
-
Stress, Physiological / metabolism*
Substances
-
Azides
-
Phenylacetates
-
3,4-Dihydroxyphenylacetic Acid
-
Benzodiazepines
-
Ethanol
-
Ro 15-4513
-
Diazepam