Ethanol prevents stress-induced increase in cortical DOPAC: reversal by RO 15-4513

Physiol Behav. 1987;40(3):383-5. doi: 10.1016/0031-9384(87)90065-5.

Abstract

Electric foot-shock increased DOPAC and decreased DA levels by about 70 and 20% respectively in the medial prefrontal cortex in rats. Pretreatment with diazepam (5 mg/kg IP) or ethanol (1.2 g/kg orally) prevented these stress-induced changes. The protective effect of diazepam and ethanol was eliminated by RO 15-4513 (5 mg/kg IP) a partial inverse benzodiazepine agonist.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism*
  • Animals
  • Azides / pharmacology*
  • Benzodiazepines / pharmacology*
  • Diazepam / pharmacology
  • Electroshock
  • Ethanol / pharmacology*
  • Male
  • Phenylacetates / metabolism*
  • Rats
  • Stress, Physiological / metabolism*

Substances

  • Azides
  • Phenylacetates
  • 3,4-Dihydroxyphenylacetic Acid
  • Benzodiazepines
  • Ethanol
  • Ro 15-4513
  • Diazepam