Exosomal lncRNAs in gastrointestinal cancer

Parisa Vosough; Seyyed Hossein Khatami; Ali Hashemloo; Amir Tajbakhsh; Farzaneh Karimi-Fard; Sina Taghvimi; Mortaza Taheri-Anganeh; Elahe Soltani Fard; Amir Savardashtaki; Ahmad Movahedpour

doi:10.1016/j.cca.2022.117216

Exosomal lncRNAs in gastrointestinal cancer

Clin Chim Acta. 2023 Feb 1:540:117216. doi: 10.1016/j.cca.2022.117216. Epub 2022 Dec 30.

Affiliations

¹ Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
² Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Islamic Azad University of Qods city, Iran.
⁴ Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
⁵ Behbahan Faculty of Medical Sciences, Behbahan, Iran.
⁶ Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
⁷ Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
⁸ Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
⁹ Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: dashtaki63@gmail.com.
¹⁰ Behbahan Faculty of Medical Sciences, Behbahan, Iran. Electronic address: ahmad.movahed14@gmail.com.

PMID: 36592922
DOI: 10.1016/j.cca.2022.117216

Abstract

Gastrointestinal cancer (GIC) remains a leading cause of morbidity and mortality worldwide. Unfortunately, these cancers are diagnosed in advanced metastatic stages due to lack of reliable biomarkers that are sufficiently specific and sensitive in early disease. There has been growing evidence that circulating exosomes can be used to diagnose cancer non-invasively with limited risks and side effects. Furthermore, exosomal long non-coding RNAs (lncRNAs) are emerging as a new class of promising biomarkers in cancer. This review provides an overview of the extraction and detection of exosomal lncRNAs with a focus on their potential role in GIC.

Keywords: Biomarker; Diagnosis; Exosomes; Gastrointestinal cancers; Long non-coding RNA.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Exosomes* / genetics
Gastrointestinal Neoplasms* / diagnosis
Gastrointestinal Neoplasms* / genetics
Gene Expression Regulation, Neoplastic
Humans
RNA, Long Noncoding* / genetics

Substances

RNA, Long Noncoding
Biomarkers, Tumor