Accounting for diversity in the design of CRISPR-based therapeutic genome editing

Krishanu Saha

doi:10.1038/s41588-022-01272-z

Accounting for diversity in the design of CRISPR-based therapeutic genome editing

Nat Genet. 2023 Jan;55(1):6-7. doi: 10.1038/s41588-022-01272-z.

Author

Krishanu Saha^{1

2

3

4}

Affiliations

¹ Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA. ksaha@wisc.edu.
² McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA. ksaha@wisc.edu.
³ Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA. ksaha@wisc.edu.
⁴ Department of Medical History & Bioethics, University of Wisconsin-Madison, Madison, WI, USA. ksaha@wisc.edu.

Abstract

CRISPR cell/gene therapy has been designed largely based on a single reference human genome. A new study reveals how human genetic diversity could lead to off-target effects and presents a novel tool to identify these risks.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

CRISPR-Cas Systems* / genetics
Gene Editing*

Abstract

Publication types

MeSH terms

Grants and funding