A G3P[9] rotavirus strain with an unusual genome constellation in a diarrheic cat in Thailand

Arch Virol. 2023 Jan 3;168(1):24. doi: 10.1007/s00705-022-05641-1.


Rotavirus infection can cause diarrhea in many animal species. A 2-year-old indoor female Siamese cat with bloody mucoid diarrhea tested positive for rotavirus (RV) group A by real-time reverse transcription polymerase chain reaction (RT-PCR). Subsequent conventional RT-PCR amplification of the 11 RV segments and sequencing revealed a G3-P[9]-I2-R2-C2-M2-A3-N2-T3-E3-H3 genome constellation. Phylogenetic analysis showed that the VP4, VP7, NSP1, NSP3, NSP4, and NSP5 genes were closely related to those of human feline-like rotaviruses, while the VP1, VP2, VP3, VP6, and NSP2 genes were genetically closest to those of human bovine-like rotaviruses, suggesting that genetic reassortment had occurred. The uniqueness of this G3P[9] feline rotavirus strain expands our knowledge about feline rotaviruses.

MeSH terms

  • Animals
  • Cats
  • Cattle
  • Child, Preschool
  • Diarrhea / veterinary
  • Female
  • Genome, Viral
  • Genotype
  • Humans
  • Phylogeny
  • Rotavirus Infections* / veterinary
  • Rotavirus* / genetics
  • Thailand