Kratom Alkaloids: A Blueprint?

ACS Chem Neurosci. 2023 Jan 18;14(2):195-197. doi: 10.1021/acschemneuro.2c00704. Epub 2023 Jan 3.


Alkaloids from the botanical Mitragyna speciosa (commonly referred to as "kratom") interact with opioid, adrenergic, serotonergic, and other receptors to provide myriad reported effects, including analgesia, energy, improved mood, and relaxation, among others. These alkaloids are complex and unique and may serve as a blueprint for the development of novel molecules to treat various substance use disorders.

Keywords: Mitragyna speciosa; kratom; natural products; novel pharmacotherapy; substance use disorder.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Analgesics, Opioid
  • Humans
  • Mitragyna*
  • Plant Extracts
  • Secologanin Tryptamine Alkaloids* / pharmacology
  • Substance-Related Disorders*


  • mitragynine
  • Plant Extracts
  • Secologanin Tryptamine Alkaloids
  • Analgesics, Opioid