Influence of Humic Acids Isolated from Raised Bog Sphagnum Peat on Development of Th1/Th2 Immune Response

Bull Exp Biol Med. 2022 Dec;174(2):236-240. doi: 10.1007/s10517-023-05680-x. Epub 2023 Jan 4.


The course administration of humic acids isolated with sodium pyrophosphate from raised bog sphagnum peat reduces the parameters of a Th1-type immune response in C57BL/6 mice, the severity of an anaphylactic shock in outbred CD1 mice, and degranulation of mast cells after their immunization with ovalbumin. The addition of humic acids increases the stimulated production of IL-4, IL-10 and reduces the production of IL-2, IFNγ by peripheral blood mononuclear cells of healthy donors.

Keywords: anaphylaxis; cytokines; humic acids; immune response; mast cell degranulation.

MeSH terms

  • Animals
  • Cytokines
  • Humic Substances* / analysis
  • Immunity
  • Leukocytes, Mononuclear / chemistry
  • Mice
  • Mice, Inbred C57BL
  • Soil
  • Sphagnopsida*
  • Th1 Cells
  • Th2 Cells
  • Wetlands


  • Humic Substances
  • Soil
  • Cytokines